Natural Killer (NK) cells are an essential component of the innate immune system and play a crucial role in anti-tumor responses. NK cell-related cancer immunotherapies include:
- Antibody therapeutics to induce NK cell–mediated antibody dependent cellular cytotoxicity (ADCC) against tumor cells (mAbs, BiKES, TriKEs)
- In vitro expansion of autologous or allogenic NK cells, as well as production of cytokine-induced memory-like NK cells for adoptive transfer into patients
- CAR-NK cells
Typical immunology research workflows to assess NK cell phenotype and function, require multiple assays.
Watch this video narration of a poster, which demonstrates use of the iQue® platform and iQue Forecyt® software, to analyze multiple NK cell function and phenotyping parameters, using a single miniaturized, multiplexed assay. An explanation of the iQue® Human NK Cell Killing Kit, with the option to add additional validated cytokines when combined with iQue® Human NK Cell Companion kits, is included.
- Poster: NK Cell-Mediated Killing and Phenotypic Analysis Using Advanced Flow Cytometry Poster
- iQue® Human NK Cell Killing Kit
- Application Note: A novel approach to evaluating NK Cell Killing
- Interrogation of natural killer cell activity using high throughput advanced flow cytometry