Functional Profiling
Phenotype and function assays are critical for selecting the top clinical antibody candidates with the desired characteristics.
The iQue Advanced Flow Cytometry Platform supports cell-based assays, by detecting target proteins in their native conformation on the cell surface, which is a better indicator of in vivo behavior.
The iQue Advanced Flow Cytometry Platform lets you perform rapid multiplexed analysis of immune cell function through simultaneous analysis of cell-mediated cytotoxicity, cell health, function, activation, phenotyping and cytokine profiling.
Epitope Mapping: Rapidly detect and visualize epitope regions for hundreds of clones with high sensitivity, and validate your data with additional information on cell health and viability— all in one assay.
ADCC Assays: Discriminate between effector and different target cell populations in the same sample using multiplexed screening assays.
Functional Profiling Research
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Maximize Efficiency in Lead Molecule Selection and Optimization
Lead selection and optimization is a crucial step in identifying molecules that meet predefined requirements and can be advanced to the next stage of development.
Octet® BLI systems are revolutionizing the speed and efficiency of selection and optimization workflows with their high-throughput and easily developed assays. These systems are ideal for applications such as affinity ranking, epitope binning, Fc-receptor binding, glycosylation screening, antibody-antigen specificity, binding characterization, and titer analysis.
With Octet® BLI systems, lead selection and optimization can be performed with greater accuracy and speed, leading to faster drug development timelines and improved outcomes.
