The immunoglobulin superfamily includes approximately 400 human proteins that comprise co-stimulatory molecules, co-inhibitory molecules, antigen & antigen receptors, cell adhesion molecules & cytoskeletal regulators and cytokine receptors. The spatial and temporal mechanisms by which these proteins elicit effects on the immune system remain to be fully defined.
This webinar highlights how researchers at Albert Einstein College of Medicine:
- Used high throughput flow cytometry for de-orphaning receptors with unknown and known ligands
- Used high-throughput site-directed mutagenesis combined with high throughput flow cytometry to dissect these interactions
- Identified the binding epitopes of function blocking monoclonal antibodies that have potential therapeutic value