Understanding the molecular mechanism of action of new chemical entities is critical to any drug discovery effort, including chemotherapeutics. It allows researchers to:
- use the function to guide specific uses for particular cancer types and patient populations
- understand uses of these drugs in combination chemotherapy
- devise new combinations based on mechanism
This on-demand webinar features an expert user presentation from the Koch Institute at MIT that highlights a functional genetic method using RNAi combined with a high-throughput GFP competition assay to evaluate mechanism of action of cytotoxic compounds in a mouse model of Burkitt’s lymphoma.
He highlights how incorporating the Intellicyt® iQue Screener platform enabled scaling-up their screens from 5 drugs/week to 20 drugs/in two days