Resources, Webinars

On Demand Webinar: Predicting Mechanisms of Action of Cytotoxic Compounds using shRNA Technology

Understanding the molecular mechanism of action of new chemical entities is critical to any drug discovery effort, including chemotherapeutics. It allows researchers to:

  • use the function to guide specific uses for particular cancer types and patient populations
  • understand uses of these drugs in combination chemotherapy
  • devise new combinations based on mechanism

This on-demand webinar features an expert user presentation from the Koch Institute at MIT that highlights a functional genetic method using RNAi combined with a high-throughput GFP competition assay to evaluate mechanism of action of cytotoxic compounds in a mouse model of Burkitt’s lymphoma.

He highlights how incorporating the Intellicyt® iQue Screener platform enabled scaling-up their screens from 5 drugs/week to 20 drugs/in two days

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